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"Statins may help treat prostate cancer"


Globe and Mail

Source: Globe and Mail

Published: 20 Sep 2022

Category: Pharmaceutical

Rating: (2½ stars)

Keywords: statin ccholesterol lowering drugs cancer prostate rosuvastatin lipitor crestor

what they said (Hover the mouse cursor over underlined words for more info)

At any given moment, numerous researchers around the world are conducting scientific studies probing how prostate cancer develops, what causes it or how the disease can be treated.

Now, a growing number of experts in the scientific community are pushing for some of those studies to examine a potentially important link between prostate cancer and cholesterol-lowering drugs known as statins. A new study by Canadian researchers, published in the September issue of the journal European Urology, is adding to those calls...

The original article can be found at: http://www.theglobeandmail.com/life/health/statins-may-help-treat-prostate-cancer/article1715479/

how did it rate? (more information)

Criteria Rating
Total Score 5 of 10
Availability of Treatment Satisfactory (?)
Novelty of Treatment Satisfactory (?)
Disease Mongering Satisfactory (?)
Treatment Options Not Satisfactory (?)
Costs of Treatment Not Satisfactory (?)
Evidence Satisfactory (?)
Quantification of Benefits of Treatment Not Satisfactory (?)
Harms of Treatment Satisfactory (?)
Sources of Information Not Satisfactory (?)
Relies on Press Release Not Applicable
Quantification of Harms of Treatment Not Satisfactory (?)

what we said (Hover the mouse cursor over underlined words for more info)

This story does something that few do: first, it comments on the quality of the study, and second, it mentions the healthy user effect (the possibility that the statin users were healthier to start with, which is likely).

That being said, the fact that the "convincing" evidence came from a large retrospective trial of mice who had received human prostate cells should not have any men (worried for their prostates) jumping for a prescription of statins. The story misses some key points including quantified risks/harms, as well as potential conflicts of interests for the featured spokespeople. In addition, the benefits mentioned in the story are only reported as relative numbers.

If statins do play a role in inhibiting prostate cancer growth, we need, as the radiation oncologist says, a large randomized trial to prove it. The two studies mentioned here generated preliminary results that should not get anyone too excited.

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